How weight gain change bone turnover with women in Anorexia nervosa

K. Tatsushima*^a (Dr), N. Tamura^a (Dr), T. Ishikawa^a (Dr), N. Sudo^b (Pr), K. Kawai^a (Dr)

^a Dept. of Psychosomatic Medicine, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba, JAPON ; ^b Dept. of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JAPON

* tatsushima-kyu@umin.net

Objective: Our objective was to investigate how bone metabolism change through body weight gain in women with Anorexia Nervosa (AN).

Patients and methods: This retrospective research at one hospital included 36 women with AN(mean age ±SEM, 30 ±11.3 years, mean BMI±SEM 12.1±1.2kg/m²) treated with our CBT program. We measured their bone mineral density (BMD) of the spine and whole body by dual-energy x-ray absorptiometry, serum intact N-terminal propeptide of type 1 procollagen (P1NP), tartrate-resistant acid phosphatase-5b (TRACP-5b) and sclerostin before and after the treatment.

Results: At baseline, BMD negatively correlated with amenorrhea duration. Upon completion, the body weight increased 8.8±2.9 kg. But they all remained amenorrhea. BMD significantly decreased (posteroanterior spine, -2.7±1.3%; whole body, -1.7±0.5%). Serum intact P1NP levels increased (P<.0001) and TRACP-5b levels decreased (P=.006), whereas sclerostin levels were stable (P=.3) over this treatment. Change in BMD did not correlate with intact P1NP and TRACP-5b levels. However, there was a significant association between change in sclerotin levels and percent change in PA spine BMD (R=0.45, P=.008). There was an inverse relationship between baseline serum sclerostin levels and percent change in whole body BMD (R=-0.54; P=.001).

Conclusions: This study demonstrates that weight gain induces bone formation and reduces bone resorption in women with severe AN regardless of BMD change. Levels of sclerostin at baseline could be a good predictor of reaction of BMD.

L’auteur n’a pas transmis de déclaration de conflit d’intérêt.